ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Extractive Spectrophotometric Determinations of Amiodarone and Ondansetron in Pharmaceutical Formulations

T. Siva Rao, P. S. N. H. Rama Chandra Rao, A. V. S. S. Prasad and C. S. P. Sastry*


Abstract:

Four simple sensitive and reproducible visible spectrophotometric methods (A-D) for the determination of Amiodarone (as hydrochloride, AD) or Ondansetron (as hydrochloride, OST) in bulk samples and pharmaceutical formulations are described. Methods A, B and C are based on the formation of ion-association complexes between AD or OST and tropaeolin oo (TPoo, lmax 420nm), tropaeolin ooo (TPooo, lmax 480nm) or wool fast blue BL (WFB, lmax 580nm). Method D is based on the formation of a molecular complex between AD or OST and cobalt thiocyanate (CTC, lmax 620nm). Regression analysis of Beer's law plots showed good concentration ranges (2.5-15, 0.6-6.0), (3.0-30, 0.5-7.5), (0.75-7.5, 0.3-4.5) and (25-300, 20-240) μg.ml-1 for (AD, OST) in methods A,B,C and D respectively. Relative standard deviations were typically

Keywords:

Spectrophotometric method; amiodarone (AD); ondansetron (OST); tropaeolin oo; tropaelin ooo; cobalt thiocyanate

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