Abstract

Amit Kumar Gautam¹, Arun Kumar², Kaushlendra Sharma³ and B. K. Rai*⁴

DOI : http://dx.doi.org/10.13005/ojc/320251

In the present work, the synthesis and structural characterization of a 2-phenyl- 3(benzamido propyl) quinazoline (3H) -4- one semicarbazone/ thiosemicarbazone hydrochloride and its metal complexes have been reported. All the synthesized compounds were characterized by using various physico-chemical techniques such as  Infrared spectra, electronic spectra, molar conductivity and magnetic susceptibility measurements. The ligand and metal ions reacted to form in the 2:1 ratio as found from the elemental analyses and general stiochiometry was determined, [M(PBPQS)₂X₂] and [M(PBPQT)₂X₂]; where M = Co(II), Ni(II) and Cu(II); PBPQS = 2-phenyl- 3 (benzamido propyl) quinazoline (3H) -4- one semicarbazone and PBPQT = 2- phenyl- 3 (benzamido propyl) quinazoline (3H) -4- one  thiosemicarbazone. On the basis of analytical data, a proposed structure for the Cu(II) complexes are distorted octahedral and those for Co(II) and Ni(II) complexes are octahedral. Ligands PBPQS/ PBPQT have been proposed to act in a bidentate manner co-ordinating to the metal ions though azomethine nitrogen and oxygen/ sulphur atom of either semicarbazone/ thiosemicarbazone moiety. The remaining co-ordination sites are occupied by negative ions such as Cl^-, Br^-, I^- or NO₃^-. The ligands and its metal complexes were tested for their possible antimicrobial potentials.

PBPQS/ PBPQT/ Co(II); Ni(II); Cu(II)/ Schiff base/ Antimicrobial studies

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