Abstract
Reductive ring opening of 3,5-bis(2-arylethenyl)isoxazoles with molybdenum hexacarbonyl: A novel route to symmetrical and unsymmetrical curcumin derivatives
Viwat Hahnvajanawong*, Thanaphat Thaima, Ruchanok Tearavarich and Parinya Theramongkol
DOI : http://dx.doi.org/10.13005/ojc/320113
Abstract:
Curcumin derivatives were successfully synthesized from 3,5-dimethylisoxazole by lateral metalation and condensation with various aromatic aldehydes sequentially at C5- and C3-methyl groups. After dehydration, further transformation of isoxazole ring to b-diketone moiety was accomplished by reductive ring opening using molybdenum hexacarbonyl [Mo(CO)6] and subsequent simple acidic hydrolysis.
Keywords:curcuminderivatives; reductive ring opening; molybdenum hexacarbonyl; lateral metalation
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