Abstract

Normah Awang¹, Nurul FarahanaKamaludin¹, Ibrahim Baba³, Kok Meng Chan¹, Nor Fadilah Rajab² and Asmah Hamid²

DOI : http://dx.doi.org/10.13005/ojc/320110

Two new organotin(IV) dithiocarbamate complexes of the type R₃SnL and R₂SnL₂ (L = methoxyethyldithiocarbamate and R = C₆H₅ or C₄H₉) were synthesized in good yields. The organotin complexes were suitably characterized by elemental analysis, FT-IR, ¹H, and ¹³C NMR spectroscopies. These complexes were prepared in situ. Elemental analysis data (carbon, hydrogen, nitrogen, and sulfur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for n(C=N), n(C=S), and n(Sn-S) in the region of 1450–1463, 992–994, and 324–326 cm⁻¹ respectively. Data for ¹³C NMR spectroscopy showed an important peak in the region of d_C197–201 ppm that corresponded to the NCS₂ group. These complexes were evaluated for their in vitroantiproliferative activities against HL-60 cell lines. The results showed that both of these complexes had high cytotoxicities toward HL-60 cell lines with the IC₅₀ values below 1 μM.

synthesis; organotin(IV); spectroscopy; dithiocarbamate; cytotoxicity

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