Abstract

Ahmed Elkhateeb^1,2, Ashwag S. Alshehri¹, Gilbert Kirsch³ and Sh. H. Abdel-Hafez^1,4

DOI : http://dx.doi.org/10.13005/ojc/320142

A mild and simple oximation reaction of 4-chloro-3-formylcoumarin with hydroxylamine hydrochloride in basic medium gave unexpected three components via oxime. Those compounds were separated in good yields by preparative TLC and by chemical means using different reaction conditions. IR, ¹H NMR, ¹³C NMR and mass spectral data confirmed the structure of the separated compounds.

4H-coumarin[3,4-d]isoxazol-4-one; ethyl-5-(2-hydroxyphenyl)-isoxazole-4-formate; methyl-5-(2-hydroxyphenyl)-isoxazole-4-formate; 4-chloro-3-cyano-coumarin

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