Abstract

Nooman A. Khalaf,  Rajashri R. Naik*, Ashok K. Shakya, Naeem Shalan and Atif Al-Othman

DOI : http://dx.doi.org/10.13005/ojc/310408

Herbs like Rosmarinus officinalis (Lamiaceae), Peganum harmala (Nitrariaceae),  Teucrium polium (Lamiaceae), Verbena officinalis (Verbenaceae),   Artemasia herba-alba (Asteraceae) and Arum palaestinum (Araceae) have been studied for its various biological activities, the extract of fresh aerial parts of  plant have not been reported for their antioxidant and anti inflammatory activities.  Our aim was to study the antioxidant, anti-inflammatory and antidiarrheal activity of ethanolic extract of fresh aerial parts of the plant. Anti-inflammatory activity was evaluated by carrageenan induced paw edema method, DPPH free radical scavenging activity (antioxidant) and effect of extract on gastro-intestinal tract motility was studied. Phenolic content of Verbena officinalis was higher (652.5 mg GAE %) than the other plant extracts. Whereas antioxidant activity is concerned the Rosmarinus officinalis exhibited highest antioxidant activity  (IC₅₀= 6.25 µg/ml), and showed excellent anti-inflammatory   (65.5% ) as compared to ascorbic acid (6.14 ± 0.09 µg/ml)  and diclofenac sodium (70.1%) respectively.  Rosmarinus officinalis leaves extract showed significant inhibition of the gastrointestinal activity (31.3 %) when compared to all the other ethanolic extracts. The ethanolic extract of Arum palaestinum Bioss did not show any significant anti-inflammatory activity nor had any effect on gastrointestinal tract inhibition

Antioxidant; anti-inflammatory; Rosmarinus officinalis

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