Abstract
An efficient and high-yielding one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones catalyzed by sodium hydrogen carbonate under solvent-free conditions
Asieh Vafaee, Abolghasem Davoodnia1, Mehdi Pordel, and Mohammad Reza Bozorgmehr
DOI : http://dx.doi.org/10.13005/ojc/310437
Abstract:
Sodium hydrogen carbonate, NaHCO3, efficiently catalyzes the one-pot, three-component reaction of phthalhydrazide, an aromatic aldehyde, and malononitrile or ethyl cyanoacetate under solvent-free conditions, to afford the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in high yields. Easy work‐up, inexpensive and readily available catalyst and avoiding the use of harmful organic solvents are other advantages of this simple procedure.
Keywords:1H-Pyrazolo[1;2-b]phthalazine-5;10-diones; Sodium hydrogen carbonate; NaHCO3; Solvent-free
Back to TOC
A New Edition of Web of Science
Journal Impact Factor
2022: 0.5
Five Year: 0.8
Journal is Indexed in
Cabells Whitelist
