Abstract

Elahe Keshavarz,^1,* Khalil Tabatabaeian², Manouchehr Mamaghani² and Nosrat O. Mahmoodi²

DOI : http://dx.doi.org/10.13005/ojc/310441

A convenient and diastereoselective method was developed for the synthesis of aldol derivatives in the presence of a catalytic amount of RuCl₃.nH₂O under solvent-free conditions. Aldol adducts were obtained in good yields and with high chemoselectivity  in short reaction times. In this protocol, aromatic and heteroaromatic aldehydes readily participate as electrophilic cross-aldol partners with a range of cycloalkanones as ketone donors.

catalytic aldol reaction; diastereoselective aldolization; green synthesis

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