Abstract

Muhammad Aqeel Ashraf¹, Abdul Wajid², Karamat Mahmood², Mohd.Jamil Maah¹ and Ismail Yusoff³

Three new series of biologically active amino substituted Schiff bases with general formula, R1 N=CHR2 . Here R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol. R2 =4-chlorobenzaldehyde, 2-chloro-benzaldehyde, salicylaldehyde, vanillin and benzaldehyde were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. Such compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear nmr (1 H, 13C). The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria, fungi and yeast. The metal complexes show more potent activities compared with Schiff base ligands.

Schiff bases; Benzthiozol; Aminophenol; Antibacterial; and Antifungal activity

[ View HTML Full Text]