Abstract

P. K. Chaudhari, K. H. Sikotra and V. H. Shah

An novel series of the pyrazolo [3,4-d] pyrimidines (IIIa-n) were prepared via one pot reaction of 4-amino-5-cyano-6-aryl-2- mercapto-5,6-dihydro pyrimidines(I) with hydrazine hydrate(II) in ethanol. Elemental analysis, IR, 1NMRand mass spectral data established identification of the compounds (IIIa-n) was evaluated for their antimicrobial activity. Some of the obtained compounds showed the interesting antimicrobial activity comparable to standard drugs like amplicillin, chloramphenicol, amoxicillin, ciprofloxacin, norfloxacin and griseofluvin.

pyrazolo [3, 4-d] pyrimidines; Antimicrobial activity and Antituberculosis activity; Antimycobacterial activity

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