Synthesis and Biological Activity of Some Urethane Derivatives of Chalkones

Hogae M. B.; Dhore N. P.; Shelar A. R.; Pawar P. K.

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Synthesis and Biological Activity of Some Urethane Derivatives of Chalkones

Hogae M. B. ,Dhore N. P. Shelar A. R. and Pawar P. K.

Department of Chemistry, Shivaji University Kolhapur-416004 India.

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ABSTRACT:

The various urethane derivatives of chalkones were prepared by condensing 2—hydroxy. 5 methyl-6 methyl, 2— benzoyl, 3—aryl, acryoophenones with phenyl isocyanate in THF in the presence of triethylarnine. These compounds were tested for their antimicrobial activity with concentration 200 μg/ml against Salmonella typhi, E. Coli and staphyl ocacii aureus bacteria. The most of them have shown promising antibactarial activity.

KEYWORDS:

Biological; Derivatives; Chalkones