Study of A Mercury Complex of an Oral Antidiabetic Drug, Tolbutamide

S. A. Iqbal and S. M. Khan

Research Laboratory of Chemistry, Saifia College, Bhopal-462 001 India.

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ABSTRACT:

Tolbutamide, (trade, Restinon) forms 2:1 complex with mercuric acetate in alcoholic medium as indicated by conductometric titrations and Job's method of continuous variation. Structure assigned to the complex is supported by analytical data and infra-red spectroscopy. Preliminary pharmacological studies conducted on a dog revealed that metal complex of this drug is more potent than the parent drug.

KEYWORDS:

Mercury; Tolbutamide,; Antidiabetic