Synthesis of some Novel 2-BenzyIthio-4-Substituted amino-6- Methylpyrimidines of Expected Antileukemic activity

K. G. Ghoneim, F. A. El-Telbany, M. El-Enany and K. Youssef

Organic Chemisry Department, Faculty of Pharmacy, Cairo University, Cairo Egypt.

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ABSTRACT:

Several series of 2-benzylthio-4-substituted amino-6-methylpyrimidines have been synthesized. Condensation of 2-benzylthio-4-chlore-6-methylpyrimidine (4) with a variety of primary amines, afforded compounds (5a-j). Reacting (5 f) and (5 g ) with formaldehyde and some secondary amines yielded the expected Mannich bases ( 6 a-c ) and ( 7 a-o ) respectively. Addition oi ( 5 h ) to aryl isocyanates and isothiocyanates gave the corresponding sulphonylureas ( 8 a_d ). Nine compounds have been screened against selected bacteria and most of them showed a moderate activity against B. subtilis and Neisseria.

KEYWORDS:

Methylpyrimidines; Expected; Antileukemic; Activity