Formation Constants of Cu(II) Complexes With 5, 6-Diphenyl-4- Aroylpyridazine-3 (2h) ones (Dapo) and -3 (2h) Thiones (Dapt)

Nabawia M. El-Guindi; Nabil A. Shams

Article | Open Access

Formation Constants of Cu(II) Complexes With 5, 6-Diphenyl-4- Aroylpyridazine-3 (2h) ones (Dapo) and -3 (2h) Thiones (Dapt)

Nabawia M. El-Guindi and Nabil A. Shams*

National Organisation For Drug Control and Research, Cairo, Egypt.

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ABSTRACT:

The stoichiometry, protonation and stability constants of 5, 6-diphenyl-4-aroylpyridazin-3 (2H)-ones (Ia-c) (DAPO) and 5, 6-diphenyl-4-aroylpyridazine-3 (2H)-thiones (Id-f) (DAPT) with Cu(II) are determined. The effect of substituent groups and some other factors affecting the metal ligand stability are briefly discussed.

KEYWORDS:

Aroylpyridazine-3; Thiones