Synthesis and Antimicrobial Activity of 8-Arylidineamtno -N-Methyl Xanthine Derivatives

khlass M. Abbass and Mosselhi A. N. Mosselhi

Department of Chemistry, Faculty of Science, Cairo University, Giza, Cairo Egypt.

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ABSTRACT:

8-Amino-caffine (4), theophylline (5) and 3-methyIxanthine (6) react with aldehydes to give the corresponding 8 arylidincamino derivatives (7-23) in high yields. The structure of products has been studied by elemental analysts and spectral methods. The antimicrobial activities of these Schiff's bases have been also investigated.

KEYWORDS:

8-Arylidineamtno -N-Methyl; Xanthine; Derivatives