Synthesis and Biological Activity of Friedel Crafts Resins: System Based on p-Methyl Anisole using Carbondisulphide as Solvent

P. M. Patel¹, Y. M. Mehta¹* K. C. Patel2** and R. M. Patel³

¹Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat 388120 India.

²Department of Biosoience, Sardar Patel University, Vallabh Vidyanager, Gujarat 388120 India.

³J. and J. Science College, Nadiad Gujarat India.

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ABSTRACT:

The low molecular weight polyketones were prepared by Friedel-Crafts reaction from p-methylanisole, ChloroacetyIchloride (CAC)and α,w-dichloroalkanes i.e. dichloromethane (DCM) and 1,2-dichloroethane (DCE)using anhydrous aluminium chloride as catalyst and carbon-disulphide as a solvent. The polyketones thus obtained were characterised by % chlorine content, IR spectroscopy and number average molecular weight (Mn) by Vapour Pressure Osmometry (VPO). The thermal properties were evaluated by Thermo Gravimetric Analysis (TGA) and Differential Scanning Calonmetry (DSC). All these resins were tested for their biological activity against bacteria, fungi and yeast. The results indicates that the growth of the tested organisms was inhibited by the polyketones to the considerable extents.

KEYWORDS:

Synthesis; p-Methyl; Carbondisulphide; Calonmetry