Palladium-Catalysed Cyclization of 3- Propargylmercapto-1,2,4 Triazine to Thiazolo [2,3-C][1,2,4]-Triazine

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Selective transformation of 3-propargylmercapto-1.2.4-triazin-5 (2H)-one (1) to 6-methylene-6,7-dihydro-4H-thiazolo [2,3-c] [1,2,4]-triazin-4-one (3) was performed under the condition of Pd (II) salt. Under basic condition the latter was isomerized to a compound which was identified to be 3,6-dimethyl-4H-thiazolo [2.3.-c] [1,2.4]triazin-4-one (4). For definite structure assignment of (4), this compound was unambigiously synthesized and its spectroscopic data were compared with those of (4).

Pd- Catalyzed; Cyclization;' Thiazolotriazine