Synthesis of Sulfoxide Derivatives of Antibacterial Interest

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A series of heterocyclic sulfoxide derivatives (l-X) were prepared by cyclization of ethyl-p-methylphenyl sulfonyl acetpacetate or diethyl-p-methyl phenylsulfonyl malonate with hydrazine, phenylhydrazine, urea or o-phenylenediamine. The prepared compounds were found to be active against E. coli.

Ethylphenyl sulfonyl acetoacetate; diethyl phenylsulfonyl malonate; pyrazole; pyrimidine; diazepine; antibacterial activity