Mass Spectral Studies of Azathioprine Analogues

Ashish K. Tewari¹, Anil Mishra¹ and D. S. Bhakuni²

¹Department of Chemistry, Lucknow University, Lucknow- 226 007 India.

²Medicinal Chemistry Division, CDRI, Lucknow - 226 001 India.

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ABSTRACT:

The mass spectral analysis of several analogues of azathioprine has been carried out .The general observation is that the nitroimidazole ring is cleaved first. The C-S-C bond is so labile that the molecular ion peak is not observed by the El technique, however it has been observed by the FD mass technique. A consistent fragmentation pattern has been observed in all the compounds.

KEYWORDS:

azathioprine; nitroimidazole; fragmentation technique