A Convenient Synthesis and Reactions of Thiazolopyrimidines and Their Antibacterial Activity

Naser Foroughifar and S. Mohamad Ali Shariatzadeth

Department of Chemistry and Biology, University of Arak, Dr. Beheshti Ave - Arak Iran.

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ABSTRACT:

In searching for compounds for biological studies it was considered worthwhile to start with 4-aryl substituted -6- methyl-2-thioxo pyrimidines 1 and 12 as new products for this synthesis. Both compounds 1 and 12 underwent cycloalkylation on heating at 80°C with acetyl chloride to afford products 8 and 15 respectively.

KEYWORDS:

biological; substituted -6- methyl-2-thioxo cycloalkylation