Design, synthesis of certain triazole derivatives bearing pyrazine moiety

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Several 4-pyrazinoyl 3 aryl/aryloxy methyl substituted 1,2,4-triazolo (3,4-b) (1,3,4) thiadiazolidine derivatives incorporating pyrazinoyl group have been synthesized. The compounds were screened for in vitro antibacterial,antifungal and antitubercular activities. Some compounds exhibited significant antitubercular and antifungal activity.

Triazole derivatives; pyrazine moiety; N-bridged heterocycles; pathogenic organisms; antitubercular activity