Synthesis and antimicrobial studies of 4-diazo-5-mercapto-3-methyl/ethyl-s-triazoles and their metal chelates

Anjali Jha^1* , Y.L.N. Murthy², G Durga³ and Mandava V. Basaveswara Rao¹

¹Department of Chemistry, Gitam Institute of Science, GITAM University, Rushikonda, Visakhapatnam - 530 045 (India).

²Department of Organic Chemistry, Andhra University, Visakhapatnam - 530 003 (India).

³Department of Chemistry, St. Josephs College for Women, Visakhapatnam - 530 004 (India).

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ABSTRACT:

4-diazo-5-mercapto-3- methyl/ethyl-s-triazoles ( 1 and 2 ) were coupled with active methylene groups viz: acetyl acetone, ethylcyanoacetate and malanodinitrile to get dinucleating ligands (L1-L6). These ligands were reacted with Ni(II) and Cu(II) chlorides. Dinucleating ligands and metal complexes were characterized by elemental analysis, IR,NMR,ESR and magnetic movement studies. On the basis of physico- chemical studies Ni(II) and Cu(II) complexes have been assigned octahedral structure. The synthesized compounds have been screened for their antimicrobial activity.

KEYWORDS:

4-diazo-5-mercapto-3- methyl/ethyl-s-triazoles; dinucleating ligands; dinuclear complexes; antimicrobial activity