Synthesis of Reactive Methylene Compounds of Malonamic Acid Series: Precursors of Bioactive Molecules

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Organic compounds containing reactive methylene group provide excellent intermediates in synthetic organic chemistry. Such substances have been found to be useful as synthon for various antitubercular, antiviral, antidiabetic, antifertilitic, antibacterial and antifungal agents. It was with these objects in view that the work described in this paper was undertaken i.e. Synthesis of different malonamic acid series from primary aromatic amines and DEM.

Reactive methylene compounds; primary aromatic amines; DEM; refluxing