Synthesis and Antifungal Activities of 2-Hydroxy-4,6-Substituted Phenyl Pyrimidine

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Flavones and chromanones are known to be biologically important compounds over 4000 chemically unique flavanoids have been identified in plant sources. These low-molecular-weight substances, found in all vascular plants, with an assortment of basic structure of phenyl benzopyrones (phenyl chromones). In the present work 2-hydroxy pyrimidine and 2-mercapto pyrimidine were prepared from phenol i.e. o-chlorophenol as a starting material. The compounds were characterized on the basis of elemental analysis their IR, ¹HNMR and screened for their antifungal activity. Some of these compounds showed significant antifungal activity. The activity was correlated with the structure.

Chalcone; Pyrimidine; Antifungal activity