Simple Spectrophotometric Methods for the Determination of Ziprasidone Hydrochloride in Pharmaceuticals Using Folin-Ciocalteau and Potassium Ferricyanide

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Two simple, sensitive and reproducible spectrophotometric methods (Method A and B) were developed for the determination of Ziprasidone in bulk and in tablet dosage forms. Method A is based on reduction of Folin-Ciocalteau reagent by the drug Ziprasidone Hydrochloride in the presence of sodium bicarbonate to form a blue colored chromogen having maximum absorption at 436 nm. Method B is based on the oxidation of the drug by potassium ferricyanide reagent to form a blue colored chromogen having maximum absorption at 733 nm. Beer’s law is obeyed in the range of 0.5 – 3 and 1-5 μg/ml for Method A & B respectively. Results of analysis were validated statistically and by recovery studies. These Methods are successfully employed for the determination of Ziprasidone in various pharmaceutical tablet dosage forms.

Ziprasidone Hydrochloride (ZPD); Spectrophotometric determination; FC reagent; Potassium ferricyanide