Energy Efficient and Greener Synthesis of Pharmacologically Important Thio-Moieties

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In the field of medicine the importance of thiosemicarbazides is well known. –N=C=S group possessing thiosemicarbazides the have been known to show pronounced biological activites. In this paper, we propose the synthesis of title compounds by the condensation of 3,4-dichloro and 2,4-dimethoxy malonamic acid hydrazides with substituted phenyl isothiocyanates under microwave irradiation. The synthesized compounds were subjected to antibacterial screenings.

Synthesis; thiosemicarbazides; microwave irradiation; antibacterial screenings