Synthesis of 5-arylidine-2-(3, 4, 5-trimethoxyphenyl)-3-(4-phenylthiazol-2-yl) Thiazolidin-4-one Derivatives as a Novel Class of Antimicrobial Agents

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The present work describes the synthesis and in vitro antimicrobial evaluation of 5-arylidine derivatives of 2-(3, 4, 5-trimethoxyphenyl)-3-(4-phenylthiazol-2-yl) thiazolidin-4-one (4). The reaction of 2-amino-4-phenylthiazole, 3,4,5 trimethoxybenzaldehyde and mercaptoacetic acid in presence of DCC yielded 2-(3, 4, 5-trimethoxyphenyl)-3-(4-phenylthiazol-2-yl) thiazolidin-4-one (4) and further 5-arylidne derivatives (5a-5k) were synthesized by the subsequent reaction of 4 withdifferent aryl aldehydes. All the synthesized compounds were characterized by standard spectroscopic techniques, evaluated their antibacterial and antifungal activity by agar well diffusion method. The compounds showed some interesting antibacterial activity. The substitution of 5-arylidne groups on new thiazolidinone (4) have resulted enhanced antibacterial activity. The compounds showed moderate antifungal activity in a scattered manner.

2-Amino-4-arylthiazole; Antimicrobial activity; 5-arylidine; 4-Thiazolidinone and 3,4,5 trimehoxybenzaldehyde