Synthesis of 3-(1-Phenyl-Vinyl)-1, 2, 5-Trioxa-Spiro Undecane and its Derivatives
1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka India.
2College of Pharmacy, IFTM, Moradabad, India.
3Department of Pharmaceutical Analysis, PES College of Pharmacy, Bangalore, Karnataka India.
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3-(1-Phenyl-vinyl)-1, 2, 5-trioxa-spiro undecane is synthetic derivative of Artemisinin. Artemisinin is a well known antimalarial drug from leaves of Artemisia annua find in china. Five different derivatives of 3-(1-Phenyl-vinyl)-1, 2, 5-trioxa-spiro undecane were synthesized using well standardized method. These compounds were purified by simple column chromatography and successfully analysed using H1NMR, IR and FAB-MS techniques.
KEYWORDS:1, 2, 4-trioxane; Artemisinin; NMR; IR; FAB-MS
