An Efficient Synthesis of 4-Thiazolidinones Derivatives

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2-(Substitutedphenyl/ 2-furanyl / 2""-thienyl)-3-(2'-ethylthiophene)-4-thiazolidinones (IIa-e) have been synthesized by cyclocondensation of thioglycolic acid with different Schiff-bases (Ia-e), which in turn were prepared by the action of different aromatic and heterocyclic aldehydes with thiophene-2-ethylamine. Cyclocondensation of Schiff-bases (Ia-e) with thiolactic acid resulted 2-(substitutedphenyl / 2""-furanyl / 2""-thienyl)-3-(2'-ethylthiophene)-5-methyl-4-thiazolidinones (IIa-e). The structure of newly synthesized compounds have been confirmed on the basis of IR, 1H NMR spectral data and physical data."

Schiff-bases; thioglycolic acid; thiolactic acid; 4-thiazolidinones; spectral data