Synthesis and Antibacterial Activity of Chalcones, Aminopyrimidines and Pyrazolines

Anjani Solankee; Smruti Lad; Ghanshyam Patel; Sejal Solankee

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Synthesis and Antibacterial Activity of Chalcones, Aminopyrimidines and Pyrazolines

Anjani Solankee*, Smruti Lad, Ghanshyam Patel and Sejal Solankee

Department of Chemistry, B.K.M.Science College,Valsad - 396 001 (India).

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ABSTRACT:

Chalcones (E1-E5) have been prepared by the reaction between ketone (D) and different substituted aromatic aldehydes. These chalcones (E1-E5) were cyclized with guanidine nitrate and hydrazine hydrate to give aminopyrimidine (F1-F5) and pyrazoline (G1-G5) derivatives corresponding chalcones (E1-E5). The synthesized compounds were characterized by the spectral data and elemental analysis. These compounds were screened for their antibacterial activity by using ciprofloxacin as standard drug.

KEYWORDS:

Chalcones; aminopyrimidines; pyrazolines; spectral data; antibacterial activity