A Convenient Synthesis and Antibacterial Evaluation of Some Novel 4-Oxo-Thiazolidines

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A new series of 4-oxo-thiazolidines (3a-e) have been prepared by cycloconndensation of hydrazones (2a-e) and mercapto acetic acid. Hydrazones (2a-e) have been synthesized by reaction between 5-bromofuran-2-carbohydrazide (1) with different aromatic aldehydes. The constitutions of newly synthesized compounds have been established on the basis of elemental analysis, IR and ¹H NMR spectral data. All the synthesized compounds have been evaluated for their antibacterial activity.

Hydrazones; 4-oxo-thiazolidines; mercapto acetic acid; spectral data; antibacterial activity