Analgesic and Anticonvulsant Activities of 2-Keto-3-(Substituted Aryl)-1-Thiazolidin-4-Ones

Download this article as: 

Sixteen 2-keto-3-(substituted aryl)-1-thiazolidin-4-ones synthesized by cyclocondensation of ketoazomethine products of five glyoxals with primary amines have been tested for toxicity ; nine products were tested for analgesic activity and eight for anticonvulsant activity. Four non-toxic new products exhibited higher analgesic activity than reference drug morphine whereas only two compounds with high LD50 values found much better in anticonvulsant action than phenytoin used as reference.

2-keto-3-(substituted aryl)-1-thiazolidin-4-ones; analgesic activity; anticonvulsant activity; toxicity; thin-layer chromatography