Syntheses and characterization of some 1, 2, 4-triazole derivatives as biological agents
1Quality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery Panipat, Haryana - 132 140 (India).
2Synthetic Research Laboratory, Department of Chemistry, Veer Bahadur Singh Purvanchal University, Jaunpur - 222 002 (India).
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3-Alkyl -4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5-one (1) when condensed with di-(3-formyl phenyl)-terephthalate (2) yielded the corresponding novel di-[3-(3-alkyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl]-terephthalate (3). All the synthesized compounds were characterized by IR, PMR, Mass spectral data and elemental analyses. All newly synthesized compounds have been assayed for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa
KEYWORDS:4, 5-dihydro-1H-1, 2, 4-triazole-5-one; di-(3-formyl phenyl)-terephthalate; condensation; cyclization; antibacterial activity
