Novel synthesis, characterization and antimicrobial activity of some new 3, 5-diarylpyrazolines

M. P. Bhise; V. M. Raut; R. P. Pawar; G. P. Gulwade; N

Article | Open Access

Novel synthesis, characterization and antimicrobial activity of some new 3, 5-diarylpyrazolines

M. P. Bhise¹,V. M. Raut¹, R. P. Pawar¹, G. P. Gulwade¹andN²

¹Department of Chemistry, Govt. Vidarbha Institute of Science and Humanities, Amravati (India).

²MCT’s Rajiv Gandhi Institute of Technology, Andheri (W) Mumbai (India).

Download this article as:

ABSTRACT:

3-Aroyl flavanones were allowed to react with hydrazine hydrate in dioxane containing little piperidine to give corresponding 3-(2-hydroxyphenyl)-4-aroyl-5-arylpyrazolines. Their structural assignment are based on elemental analysis, spectral data (IR, UV & NMR) and chemical properties. All these compounds were tested in vitro for their antibacterial activity by disk-diffusion method against gram positive and gram negative bacterias. In some of the compounds the results are found to be encouraging.

KEYWORDS:

3-(2-Hydroxyphenyl)-4-aroyl-5-arylpyrazoline; Antimicrobial activity