Synthesis and antimicrobial activity of some new 2,5 disubstituted 1,2,4-triazoles

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Aniline, 4-Chloro aniline, 3,4-dichloro aniline were treated with carbon disulphide and concentrated ammonia in the presence of lead nitrate and methanol to get 1-Phenyl, 4-chlorophenyl, 3,4-dichlorophenylisothiocynates respectively. Ethyl benzoate, methyl salicylate, 4-hydroxy methyl benzoate, 4-amino ethyl benzoate, 2-bromo ethyl benzoate, 4-bromo ethyl benzoate, 3,4-dimethoxy benzoates were treated with hydrazine hydrate(98%) in presence of absolute ethanol to get their respective substituted benzo hydrazides. which are further treated with 1-phenyl, 4-chlorophenyl, 3,4-dichlorophenyl isothiocynates in presence of absolute ethanol to get their respective substituted Thiosemicarbazides.which are undergo dehydrative cyclization with concentrated sodium hydroxide to furnished with corresponding substituted 1,2,4-triazoles.the newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.

Triazole; phenylisothiocynates; benzohydrazide