Synthesis and Pharmacological Studies of Some New 11H- Indolo[3,2-C] Isoquinolin-5-Ylthio)Acetyl Thiosemicarbazide Andits Derivatives

Download this article as: 

8-methyl 11H-indolo [3,2-c] isoquinolin -5-ylthio) acetyl thiosemicarbazide (II) was prepared by the reaction of 8-methyl-11 H-indolo[3,2-c] isoquinolin-5-yithio) acetic acid hydrazide (I) and ammonium thiocyanate. Acetyl thiosemicarbazide (II) was converted into 5-[(8-methyl 11H-indolo[3.2-c]isoquinolin- 5-ylthio) methyl)-2-amino-1,3.4-thiaiazole (III) and 5-[(8-methyhl 11H-indolo[3 2-c]isoquinolin-5-ylthio) methyl]-4H-1,2,4-triazole-3-thiol (IV) by cyciodehyciration with phosphoric actd and alkali cyclization at reflux conditions, respectively. Compound (IV) on reaction with ethytchloroacetate yielded ethyl 5-[(8- methyl 11H-indolo [3,2-c]isoquino-5-ylthio) methyl}-1,2.4-triazole-3-thio] acetate (V) .The structures of these compounds were confirmed by their spectral studies. All the unknown compounds were tested for their various pharmacological activities such as analgesic anti-inflammatory, antheimentic and antibacterial activities.

Thiosemicarbazide; ylthio; methyl; cyciodehyciration isoquinolin