Novel Spectrophotometric Method for the Determination of A Atorvastatin Calcium in Pharmaceutical Dosage forms

S. V. Saradhi¹*, G. D. Rao², T. V. reddy, J.v Kumar³, M. Sai Raghava³ and M. Y. L. N. Kishore³

¹Department of Biotechnology, Koneru Lakshmaiah College of Engineering, Vaddeswaram - 522 502 (India) ²K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada - 520010 (India) ³P.B. Siddhartha College of Arts and Science, Vijayawada - 520 010 (India)

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ABSTRACT:

A simple, sensitive and reproducible spectrophotmetric method is developed for the determination of Atorvastatin calcium in bulk and dosage forms. This method is based on the formation of colour species on binding of Atorvastatin calcium with concentrated nitric acid and ferric nitrate to produce pale green coloured solution (l max at 400 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of Atorvastatin calcium in various pharmaceutical preparations.

KEYWORDS:

Atorvastatin calcium; Visible Spectrophotometric determination; Beer’s Law