Synthesis and Antihistaminic Activity of Chromon [2′, 3′:6,7] [1,3,4]-Thiadiazepin [2,3-B]-6′- Substituted Quinazolin-4(3H)-Ones

Alok Sharma¹, Shailendra Patil², G. Achaiah³ and Asmita Gajbhiye¹

¹Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya Sagar (India) ²Globus College of Pharmacy, Bangarasia, Bhopal (India) ³Medicinal Chemistry Research Lab, University college of Pharmaceutical Sciences, Kakatiya University, Warangal (India)

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ABSTRACT:

A series of six title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum. The activity of chromone[2',3':6,7][1,3,4]thiadiazepine (2,3-b)6’-iodoquinazolin-4(3H)-one (7f) was comparable to that of standard drug pheniramine maleate at the dose of 50 μmol.

KEYWORDS:

in vitro Antihistaminic activity; Substituted quinazolin