Synthesis of 2-Substituted Amino-4-(1-Substituted Thio-Carbamido-3-Yl)-6-Substituted Imino-1,3,5-Thiadiazines

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Novel series of 2-substitutedamino-4-(1-substitutedthiocarbamido-3-yl)-6-substitutedimino-1,3,5-thiadiazines[2a(i) to 2f(iii)] have been obtained by basification of their hydrochloride [1a(1) to 1f(iii)],which are prepared by the interaction of 1,3-Bis-(n- substitutedthioamido) guanidine and substitutedisocyanodichloride. The latter were prepared initially by the condensation of aryl/alkylisothiocyanate and guanidine carbonate in 1:2 molar ratios. The structure of all these compounds were established on the basis of elemental analysis, IR and PMR spectral data.

Novel series; 2-substitutedamino-4-(1-substitutedthiocarbamido-3-yl)- 6-substitutedimino-1;3;5-thiadiazines