Studying the Relation Between the Antibacterial Activity and the Chemical Activity of the 2-Formylpyridine, 2-Formylfuran, 2-Formylthiophene and 2-Formylpyrrole

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Some crossed aldol and oxime products were synthesized and the yield have been used as a measure for the chemical reactivity of the 2-formyl pyridine, 2-formyl furan, 2-formyl thiophene and 2-formylpyrrole, which compared with the antibacterial activity to the mentioned 2-formyl compounds to indicate that there is a relation between the antibacterial activity towards E. coli bacteria and electrophilicity of the carbonyl compounds toward nucleophiles.

Antibacterial activity; Chemical activity; 2-formylpyridine; 2-formylfuran; 2-formylthiophene; 2-formylpyrrole