Synthesis and Anti-Tumour Activity of Some Indolizine-2-Carbonylamino Acid Derivatives

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Few amino acid derivatives of indolizine-2-carboxylic acid have been synthesized by converting of Indolizine-2-carboxylic acid to acyl chloride, followed by condensation with various amino acids. The starting material of Indolizine-2-carboxylic acid was prepared by aldol type condensation of ethyl bromopyruvate with á-picoline. These synthesized compounds, indolizine-2-carbonylamino acid derivatives were screened for anti-tumour activity using Erhlich Ascites Carcinoma (EAC) Cell induced albino mice. The compounds IIIa and IIId showed significant anti-tumour activity, IIIb and IIIc were found to be moderately active and remaining were inactive.

Indolizine-2-carboxylic acid; anti-tumour; amino acids