Synthesis and Antimicrobial Activity of Some New N(4-Fluoro-3-Piperazinyl) Phenyl Benzaldimine Derivatives

M. Srinivasa Murthy, L. V. G. Nargund, Gopala Krishna Rao and P. N. Sanjay Pai

Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy Hosur Road, Bangalore- 560 027 (India)

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ABSTRACT:

A series of N(4-fluoro-3-piperazinyl)phenylbenzaldimine derivatives II were prepared by the reaction of N(3-chloro-4-fluoro)phenylbenzaldimine derivatives I with piperazine. The structures of new synthesized compounds were confirmed by their spectral studies and these compounds were tested for their in vitro growth inhibitory activity against Gram +ve and Gram -ve bacteria.

KEYWORDS:

Benzaldimine derivatives; Antimicrobial activity