Synthesis and Screening of Some 4-Substituted-3,5-Dimethyl Pyrazoles for Analgesic and Anti-Inflammatory Activities

Prasant Pathak, Ashutosh Mishraa and M. S. Vijay Kanthb*

Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar- 470 003 (India)

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ABSTRACT:

Some 4-carboxyphenyl and 4-(carboxyphenyl)-amino 3,5-dimethyl pyrazoles have been synthesized by cyclization of 3-(carboxyphenyl)-aminoacetylacetone and 3-(carboxyphenyl) acetylacetone with hydrazine sulphate and screened for analgesic and anti-inflammatory activities.

KEYWORDS:

Pyrazole derivatives; Analgesic; Antiinflammatory activities