Synthesis and Characterization of Schiff Bases of 2′-Amino-4′-(3-Coumarinyl) Thiazole as Potential Nsaids

B. S. Jayashree, Justin Jerald and K. N. Venugopala

Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Hosur Road, Bangalore- 560 027 (India)

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ABSTRACT:

A series of schiff bases of aminothiazolyl coumarin were synthesized by treating 2'-amino-4'-(3-coumarinyl) thiazole with aldehydes. The former compound was obtained by cyclizing 3-bromoacetyl coumarin with thiourea. The structures of the synthesized compounds have been characterized on the basis of spectral data such as IR, 1H-NMR and Mass Spectral (MS) studies and evaluated for analgesic and anti-inflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and anti-inflammatory activity.

KEYWORDS:

Schiff bases; Aminothiazolyl coumarin; Analgesic; Anti-inflammatory activity