Synthesis and Antimicrobial Activity of Imidazole-Quinazoline
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ABSTRACT:Imidazole-Quinazoline derivatives VI(a-j) and VII(a-j) were prepared from 3-amino-2-(Substituted Phenyl)-4-oxo quinazoline when 4-phenyl methylene-2-(4'-nitro phenyl)-5-oxo-1, 3-oxazole reacted with 3-amino-2-(substituted phenyl)-4-oxo quinazoline in presence of POCl3 in pyridine gave derivatives VII(a-j) and if reacted with 4-(3',4',5'-Trimethoxy phenyl methylene)--(4'-nitro phenyl)-5-oxo-1-3-oxazole in same condition gave derivatives VII(a-j). These compounds were characterized on the basis of elemental and spectral analysis. All the newly synthesized compounds were tested for their anti-microbial activity.
KEYWORDS:Imidazole-Quinazoline derivatives
