Synthesis and Evaluation of Antibacterial Activities of Hydrazones of 6-Nitro 1,4-Quinoxaline Derivatives

Suroor A. Khan; Anees A. Siddiqui; Zia Ur Rehman

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Synthesis and Evaluation of Antibacterial Activities of Hydrazones of 6-Nitro 1,4-Quinoxaline Derivatives

Suroor A. Khan, Anees A. Siddiqui and Zia Ur Rehman

Department of Pharmaceutical Chemistry, Faculty of Pharmacy Jamia Hamdard, New Delhi- 110 062

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ABSTRACT:

Hydrazones of 6-nitro 1,4-Quinoxaline derivatives are synthesized by condensing substituted quinoxalines and hydrazine hydrate, followed by reaction with respective aldehydes. These are characterized on the basis of IR, NMR and mass spectral data. The final compounds were evaluated for antibacterial activity by taking Staphylococcus aureus as test organism.

KEYWORDS:

6-nitro 1;4-quinoxaline; hydrazones; antibacterial activity