Synthesis of Some New 5-Oxoimidazoline Derivatives as Potential Antimicrobial Agent

Hasmukh Kanjariya, Devendra Verma and Hansa Parekh*

Department of Chemistry, Saurashtra University, Rajkot - 360 005

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ABSTRACT:

2-(o-Chlorophenylaminosulpho)-4-anisidine 1 has been condensed with different azlactones to yield 5-oxo-imidazolines 2a-k in good yield. All the compounds have been evaluated in vitro for their antibacterial activity against Gram positive. Gram negative bacterial strains, fungi and antitubercular activity against Mycobacterium tuberculosis H37 Rv. The constitution of these products have been outlined by elemental analyses, IR, NMR spectral study and further supported by mass spectrometry.

KEYWORDS:

5-Oxoimidazolines; Antitubercular; Antimicrobial