Synthesis and Antibacterial Activity of 1-Isonicotinyl-3-Methyl-4-(Substituted Phenyl Hydrazono)-2-Pyrazolin-5-one

Mohammed Amir; S. M. Hasan; A. Wadood

Article | Open Access

Synthesis and Antibacterial Activity of 1-Isonicotinyl-3-Methyl-4-(Substituted Phenyl Hydrazono)-2-Pyrazolin-5-one

Mohammed Amir*, S. M. Hasan and A. Wadoo

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard New Delhi-110 062 (India)

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ABSTRACT:

Various 1-isonicotinyl-3-methyl-4-(substituted phenyl hydrazono)-2-pyrazolin-5-one were synthesized and evaluated for their antibacterial activity. The compound showed significant antibacterial activity against Staphylococcus aureus (Gram +ve) and Escherichia coli (Gram -ve) bacteria by agar plate diffusion method.

KEYWORDS:

Pyrazolin-5-one; Antibacterial activity