Synthesis and Antimicrobial Activity of Some Aryl Amide and Sulphonamide Derivatives Bearing Thiadiazole Nucleus

Kartik Ladwa, Ranjan Khunt and Hansa Parekh*

Department of Chemistry, Saurashtra University, Rajkot- 360 005 (India)

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ABSTRACT:

A series of new 1,3,4 thiadiazoles have been synthesised by condensation of different aryl sulfonylchlorides or aryl acid chlorides with 2-amino-5-(a-methyl-4'-isobytylbenzyl)-1,3,4-thiadiazole. The physical and spectral data of the synthesised products have been studied. The synthesised products are screened for their in vitro antibacterial activity, against bacteria such as B. megaterium, S. pyogens, E. coli, K. pneumonias and fungi S. cerevisice.

KEYWORDS:

Antimicrobial activity; aryl amides; sulphonamides