Tephrospinosinol, a flavonol glucoside from Tephrosia spinosa

A. Thirupathaiah¹*, Bernard Bodo² and G. Venkateshwar Rao¹

¹Department of Chemistry, Kakatiya University, Warangal - 506 009 (India). ²Laboratoire de Chimie et Biochimie des Substances Naturelles, UMR 5154, CNRS, Muséum National d’Histoire Naturelle, CP54, 63 rue Buffon - 75005, Paris, (France).

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ABSTRACT:

A flavonol glycoside tephrospinosinol 1 has been isolated from the MeOH extract of the Tephrosia spinosa by various chromatographic methods. The structure of tephrospinosinol¹ was established by physical and spectroscopic analysis. Application of 2D NMR techniques was useful for complete characterization of the new tephrospinosinol 1 and it is identified as 5,4'-dihydroxy,6,7-dimethoxy,flavone 3-o-β-glucopyranoside. Tephrospinosinol 1 shows moderate antibacterial and low antifungal activity.

KEYWORDS:

Tephrospinosinol; 5;4'-dihydroxy; 6;7-dimethoxy,flavone3-O-β-glucopyranoside; Tephrosia spinosa; antimicrobial activity